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Activation of endogenous Factor V by a homocysteine-induced vascular endothelial cell activator

For the azido-tagged small molecule (three-step) or azido-tagged dyes screen, 90 L of the cell culture was added into each well containing 10 L of the azido-tagged small molecule/dye at 500 M in 96-well plates, covered with plastic film, and incubated for 1 h at 37 C in a shaker incubator

HennessyAABarrettEPaul RossRFitzgeraldGFDeveryRStantonC

APR-246 and inhibitors of the cystine/glutamate antiporter, system x C , take advantage of this vulnerability to selectively kill mut-p53 cancer cells