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Increasing ME2 activity in the mitochondria increases the level of NADPH there in order to counteract ROS production, which represents a unique function of ME2 in the mitochondria, whereas PFK in the cytosol lacks antioxidative capability (Fig

Glutamine is a neutral amino acid and thus does not induce a negative charge burden in the mitochondrial matrix, which is already more negatively charged than the cytosol

Research literature characterised honestly qualified throughout ("research models," "in vitro/in vivo/clinical" distinction made explicit), no overstatement