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Materials and Methods Animals Adult C57BL/6 male mice aged 68 weeks and weighing 2026 g were purchased from the Animal Center of the Chinese Academy of Sciences (Shanghai, China)

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Microglia and astrocytes fractal analysis was performed as described ( Supplementary Figure 2 ): colorized images ( Supplementary Figure 2a ) were transformed to 8-bit grayscale to best visualize all positive staining ( Supplementary Figure 2b )

Glutathione peptide is a tripeptide compound composed of glutamic acid, cysteine, and glycine that functions as a critical intracellular antioxidant and detoxification agent