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Uncontrolled activation and excessive expression of splicing XBP-1 contribute to endothelial apoptosis and eventually AS evolution, as discovered in the branches and plaques of arteries in ApoE knock-out mice, which may also be related to induction of VSMC calcification (94, 95) (Figure 2B)

Sorokin A, Bitner L, Wu J, Menter D, Kopetz S , Morris VK

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