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Erythrocytes dont have the intrinsic apoptotic machinery upstream of caspase-3, including cytochrome c or apoptotic peptidase-activating factor 1 (APAF-1) [22, 23]

doi: 10.1111/j.1600-079X.2010.00821.x 160 NelsonP

This multidimensional molecular strike ultimately triggers the physical disintegration of the microvascular barrier, allowing protein-rich fluid to seep unimpeded into the alveolar space, forming the characteristic non-cardiogenic pulmonary edema of ARDS

Glutathione Reduced Form 2

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