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The most frequent offenders are (in this order) wheat, dairy, eggs, and corn

The most critical class of ligands for innate immune receptors consists of nucleic acids: exogenous DNA, RNA released during viral infection, and double-stranded RNA (dsRNA), which serves as an intermediate in viral RNA-dependent replication [211]

For instance, the disruption of tightly regulated metabolic pathways can lead to adverse reproductive outcomes, such as an inefficient energy supply to germ cells, defects in sperm motility, or arrest of spermatogenesis (129)

Further, the study may not have adequately considered differences in response to microneedle patches in different individuals (e.g., based on age, sex, and health status)

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