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For LTP, repetitive and strong depolarization of the neurons allows significant influx of Ca 2+ into the cytoplasm and activation of protein kinases, including the calcium/calmodulin-dependent protein kinase II (CaMKII), which (a) phosphorylate and activate AMPA-Rs and (b) trigger the insertion of additional AMPA-Rs into the postsynaptic membrane [35]

Autoimmune diseases also cause it when the bodys defense system mistakenly attacks healthy tissues, creating a cycle of inflammation

Clinical use of Hypericum perforatum (St Johns wort) in depression: a meta-analysis

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PLoS One 9 , e106804 (2014)