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Diarrhea and constipation are also commonly observed, each potentially affecting ten to fifteen percent of patients, with individual susceptibility varying based on factors such as baseline gastrointestinal function, dietary habits, and concurrent medications

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The SCN, located in the hypothalamus, functions as the bodys master clock (Patton and Hastings, 2018)

Constipation management Constipation responds well to proactive management: Increase water intake to at least 2.5 to 3 liters daily Add fiber gradually through diet or supplementation (psyllium husk works well) Maintain physical activity as movement stimulates gut motility Consider magnesium supplementation (magnesium citrate or oxide), which has natural laxative properties Avoid foods that worsen constipation such as processed foods, excessive dairy, and refined carbohydrates These strategies align with general recommendations for anyone experiencing peptide-related digestive changes