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One notable study investigated the effects of R (+)-thioctic acid, a biogenic antioxidant, on OS and peripheral neuropathy in diabetic patients, indicating significant improvements in OS markers and nerve conduction velocity ( A RCT study demonstrated that ALA supplementation significantly alleviated neuropathic symptoms in patients with DPN

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A., Fernandes, R

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Indeed, although both proteins impair plasma TG clearance when bound to TRLs, their impact on HDL functionality is opposite: apoC3 exerts a negative effect and apoC1 a positive effect on the atheroprotective functions of HDL, including its inhibitory effect on CETP (see Table 1)