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Considerations for Linker Design of drug conjugates Drug Conjugate Linkers Effect on the PK, Efficacy, and Toxicity Profiles Hydrophilicity is crucial for the development of antibody-drug conjugates, and low hydrophilicity of the linker can cause many problems, such as low coupling efficiency, deposition of ADCs in plasma, and non-specific uptake of ADCs in tissues, and so on

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In addition, marked suppression of HCC cell growth was observed both in vitro and in vivo following treatment with a combination of wild-type p53-induced protein phosphatase 1 and PARP inhibitors (138)