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Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

In a hypoxic and glucose-deprived TME, The metabolism of Gln is essential for tumor cells to survive and multiply ( Additionally, metabolomic analyses reveal low levels of Gln and elevated levels of glutamate in TNBC, suggesting that TNBC is more dependent on Gln and more sensitive to therapies targeting Gln breakdown compared to other breast cancer subtypes ( The role of Gln is critical in both the proliferation and metastasis of cancer cells

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Endocrinol., 1998

a small almost-invariant DNA motif or protein domain -- functioning as an enzyme active-site, cofactor docking site or ligand-binding site -- is further evidence of divergence from an ancestral gene