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Factors that increase the risk of acetaminophen toxicity: Chronic alcoholism (not acute alcohol intoxication) Malnutrition Drugs that increase acetaminophen toxicity (INH, rifampin, phenobarbital, phenytoin, carbamazepine, trimethoprim-sulfamethoxazole, zidovudine) Altered pharmacokinetics Extended-release acetaminophen preparations Delayed gastric emptying (e.g

Methimazole is typically the first-line treatment due to its favorable dosing regimen and safety profile, while propylthiouracil is reserved for specific clinical scenarios such as pregnancy or severe toxicity