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The cause of endolymphatic hydrops is unclear, and while all patients with Mnire disease have endolymphatic hydrops, not all patients with endolymphatic hydrops have Mnire disease, which has led to the suggestion of an array of possible causes including genetic predisposition, viral infection, and multiple other biochemical and immune factors

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Furthermore, HDL dose-dependently inhibits stimulated platelet activation, which leads to reduced platelet aggregation, granule secretion and fibrinogen binding