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Russo M, Chen M, Mariella E, Peng H, Rehman SK, Sancho E, et al

However, a randomized phase III clinical trial, IMBRAVE 150 (NCT03434379), demonstrated significant improvements in co-primary end points, PFS and OS, using the combination of atezolizumab (anti-PD-L1) and bevacizumab (anti-VEGF-A) compared with sorafenib 95

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It also activates lysyl oxidase (LOX), the copper-dependent enzyme responsible for collagen and elastin crosslinking in the extracellular matrix