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specifically, it inhibits pro-apoptotic mediators such as Bax and cleaved caspase-3 while simultaneously upregulating anti-apoptotic proteins like Bcl-2, thereby stabilizing mitochondrial integrity and obstructing cytochrome-cdependent cascades ( 3.5 Effects on protein aggregation Luteolin exerts its influence on proteostasis through various mechanisms: it has the capacity to diminish the production and aggregation propensity of misfolded proteins indirectly by attenuating oxidative stress and neuroinflammation that promote misfolding, as well as by modulating proteolytic systems (40)

These side effects will have to be taken into consideration when determining appropriate dosing for chronic disorders

Researchers use SLU-PP-332 in controlled lab settings

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Protection of patients in clinical trials is the paramount responsibility of the institution in which the study is being conducted