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3IP), Azgp1 also shows positive correlations with enzymes involved in protein metabolism and oxidative stress responses, further supporting its antitumour potential: (1) LAP3: This enzyme regulates amino acid turnover, affecting protein synthesis and signalling pathways critical for cell function 57

It is hypothesised that both the anti-tumour response and the development of irAEs are representative of a robust immune reaction, where self-reactive T cells infiltrate both tumours and the organs that develop irAEs

Bottom line: Morning doses act as a protective shield for the day ahead, while evening doses support the body's internal repair and detoxification work that happens during sleep

[Effects of chronic Semax administration on exploratory activity and emotional reaction in white rats]