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To identify the exact location of binding sites for the predicted TFs, we detected the motif occurrences in the promoter regions ( 500 bp from a transcription start site) of genes from the gene sets using HOCOMOCO collection v.11 89

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To accommodate this wide range of peptide ligandsfrom small oligopeptides to larger polypeptide hormonespeptide-binding GPCRs exhibit structural diversity, allowing them to selectively recognize and respond to a broad spectrum of physiological signals 62,63