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The potential explanation for sex differences in the IGF-1 signaling pathway on aging as well as response to other age-delaying interventions is unclear, but unique interactions of candidate pathways and targets with sex hormones could explain in part these disparate effects

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Polyphenols were identified by matching retention time and m/z ([M-H] ) with authentic standards

Following the elevated FSH level, the antral follicles produce inhibin and estrogen, with negative feedback on FSH

Yuen, orcid.org/0000-0002-8169-2728 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers