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Nitric oxide preferentially induces type 1 t cell differentiation by selectively up-regulating IL-12 receptor 2 expression via cGMP

Patients were randomized 3:1 in a blinded manner to receive resmetirom 80 mg or matching placebo given orally once daily in the morning for the duration of the study (until the required number of Composite Clinical Outcome events are achieved)

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After very high doses of aspartame (100, 150, and 200 mg/kg bw), mean peak plasma phenylalanine concentrations were approximately proportional to the administered dose, and considerably higher than the normal postprandial range (Stegink et al., 1980, 1981a)