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10.1128/JVI.00265-07 J

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In models of myocardial infarction, dapagliflozin significantly decreases Cu 2+ accumulation and reactive oxygen species (ROS) generation by inhibiting the HIF-1/TGF- signaling pathway and downregulating the copper transporter CTR1, which enhances copper uptake and mitigates copper-induced myocardial fibrosis [73]