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The highest content of spermidine can be found in bean seeds, especially in soybeans, and in mushrooms, ranging approximately 100200 mg/kg

doi:10.1016/0014-2999(93)90100-v

The improvements in mitochondrial function and reductions in ROS levels that occur after NMN treatment positively affect the body's health status and are accompanied by considerable decreases in the levels of expression of the proinflammatory factors IL1 and TNF in the serum

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Despite this challenge, leukemia cells spread to the CSF, requiring aggressive central nervous system (CNS)-directed treatment that can lead to neurotoxicity