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The age-related changes are considered to be similar to those observed in HGH deficiency, and from this point is where the controversy begins, as it is observed, at least in model animals, that this deficiency or resistance has points in favor of prolonging life expectancy

However, the evidence for chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) remains limited, and NICE guideline NG206 does not recommend supplements as a treatment for ME/CFS

These findings offer a novel insight into how autophagy modulates zinc homeostasis in cancer cells

Cell Stem Cell 10 , 96103 (2012)

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