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Both OH and ONOO are very highly reactive and destructive to the RPE and photoreceptors, as has been shown to occur in AMD ( 2 O 2 to the OH via the Fenton reaction, iron dyshomeostasis in the retina aids in the development of AMD by activating the ferroptosis pathway, which leads to loss of the RPE cells and degeneration of photoreceptors ( Figure 4 Mitochondria, whose number varies among cells, are essential to the energy requirements of the cell

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