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For controlled skin studies, topical application removes the confounders introduced by injection no injection site reactions, no systemic distribution diluting local concentration, no injection technique variability across research subjects

While some people notice improvements in mental clarity or energy within a week, the most significant benefits for cellular health and resilience usually become apparent after 4 to 8 weeks of consistent use

Med 376 , 24592469 (2017)

Zhang X, Sharma PK, Goedegebuure SP, Gillanders WE

This drug was found safe and effective in five patients with dermatomyositis to the point that prednisone was reduced or discontinued (120)