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The potentially deleterious effects of hyperhomocysteinemia are a consequence of inadequate levels of the methyl donor 5-methyltetrahydrofolate (5-MTHF) Citation[64,68]

Mol Cancer Ther (2019) 18(11):193746

These effects arise from both direct microbehost interactions. Dysbiosis markedly diminishes the physiological tolerance of intestinal tissues to ferroptosis, thereby compromising the intestinal barrier function and exacerbating colitis (114)

66 DelangheT.HuygheJ.LeeS.PriemD.Van CoillieS.GilbertB.et al (2021)

Note : It is important to note that these results, while promising, were obtained on a porcine model rather than a human skin model