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The study found that ANKO mice, which lack NAMPT in both brown adipose tissue (BAT) and WAT, showed disturbed gene programs involving thermogenesis and mitochondrial function in BAT, resulting in a dampened thermal response

This metabolic safety profile expands the potential population who might safely use the peptide under medical supervision

However, as Fragment 176-191 is a research chemical and in vivo testing is prohibited, there remains a paucity of published data on administration via subcutaneous injection

on alternate days until there is no further improvement