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These extras can not only reduce the supplements effectiveness but may also lead to unwanted side effects or allergic reactions

A pilot trial of melatonin in 22 breast cancer patients receiving paclitaxel- or docetaxel-based chemotherapy reported that 21 mg of daily melatonin appeared to reduce CIPN incidence (45%) and severity compared to historical controls (~60%) without impacting quality of life (Nahleh 2010)