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Dermatomyositis most commonly occurs in children between 5 and 15 years old, or adults in their late 40s to early 60s

These include inhibiting DNA binding activity of EBNA1 (351, 352), disrupting homodimerization (353), blocking its interaction with key host cellular proteins, such as USP7, CK2 or targeting its oncogenic partners, such as MDM2 (354)

The key residues in both GSH_a and GSH_b binding modes are located in the C1 region (N259 and E255), it is evident that for GSH, the C1 region of mTYR is the critical binding area

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Finally, our results demonstrate that androgen signaling serves as a potent stimulating signal driving HHEX expression in the adrenal at puberty, but other hormonal factors, such as estrogens, might also influence adrenal functions and were not addressed in the current study