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One of the earliest synthetic prebiotics developed is lactulose, which is shown to increase gut bacteria, enhance water retention in stools, and is thus associated with laxative effects

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"Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle"

Resveratrol, a polyphenol found in grapes and red wine, exerts protective effects through sirtuin 1 (SIRT1) activation, modulation of mitochondrial function, and attenuation of oxidative damage [114]

Diabetic hyperglycemia triggers paradoxical glycolysis suppression despite energy deficits, while microglial advanced glycation end products (RAGE) receptors, a dual insult exacerbating acidosis and neuroinflammation, are evidenced by diabetics exhibiting 3 higher lactate/penumbra volume ratios than non-diabetics [46, 129]