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So even though they are no longer formally restricted by Category 2, the affirmative basis to compound them at scale still doesnt exist

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These include: 1) oxidative stress and mitochondrial damage, where viral factors induce ROS accumulation and mitochondrial dysfunction, leading to cellular damage, impaired autophagy/mitophagy, and primed inflammatory pathways

EMT is characterized by the downregulation of cell-cell adhesion molecules, including E-cadherin, and the upregulation of mesenchymal markers, such as SMA, fibroblast-specific protein 1 (FSP1), fibronectin, collagen, and vimentin (70)

FIGURE 9 Discussion Nrf2 is a key member of cap-n-collar basic leucine zipper transcription factor family, and is also a key regulator of mammalian genes involved in cell protection and detoxification by preventing oxidative stress ( As the first step of metabolism, the liver is often exposed to high concentrations of exogenous and endogenous metabolites, especially vulnerable to oxidative damage caused by intermediate active substances