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Tag El Din were added to the revised paper without explanation and without exceptional approval by the editor, which is contrary to the journal policy on changes to authorship

Effective T-cell activation requires both T-cell receptor binding to the major histocompatibility complex and a secondary costimulatory signal achieved through the interaction of CD28 on the T cell with B7 on the antigen-presenting cell

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That distinction is what determines action

Mair, W., Goymer, P., Pletcher, S