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Secondary metabolites from the South China Sea invertebrates: chemistry and biological activity

In addition, PARylation has been strongly implicated in SG formation, suggesting that it might be a critical modifier for the dynamic assembly/disassembly of disease-related RNP granules, including disease-related RBPs, such as the FET family and TDP-43 129

Results obtained from randomized clinical trials, however, were inconsistent and in some circumstances have indicated that antioxidants increase cancer risk ( N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression ( From these data we can reasoned that by selectively targeting GSH content of cancer cells we can induce apoptosis either directly or by combining therapies with redox antineoplastic agents

(2017) 15:e04780