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The ELF GSH levels after the rest period was the expected 250 M but when the mice were sacrificed immediately following the third day of CS exposure the ELF GSH levels were no different than control levels unlike the nave mice which CS exposure depleted the ELF GSH levels by 50% (Figure 4A)

When combined with tirzepatide, which improves insulin sensitivity, the net effect is likely neutral or positive, but this has not been formally studied