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The hypothesis that deficient serotonergic neurotransmission contributes to the pathogenesis of MDD originated from clinical observations that amine-depleting drugs induced depressive states, whereas monoamine oxidase inhibitors, which prevent the breakdown of serotonin (5-HT), alleviated depressive symptoms [4, 5]

, 378 , 319-332, Sharapov, M

Over the last years, there have been some advancements in understanding the etiology and pathogenesis of CVS

Danthi P

Obviously, berberine has been shown to have a potent anti-inflammatory impact in cases of severe abdominal infection and to mitigate intestinal mucosa injury due to stressful conditions (Wang et al