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Additionally, in surveys conducted across multiple regions, despite 94.6% of respondents reporting at least partial familiarity with treatment processes, direct potable reuse continues to face rejection, as affective responses and perceived health risks often outweigh technical understanding and scientifically verified safety assurances 123

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Despite increasing attention, current evidence remains limited to in vitro and animal research, with important gaps in long term data and standardized methodologies

In general, these undesirable effects occur at the beginning of therapy with growth hormones and also depend on the dose