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CMS Innovation Center models are assessed for their impact on quality of care and expenditures under Medicare, Medicaid, and the Children's Health Insurance Program (CHIP) and the scope and duration of the model test may be expanded through rulemaking if expected to either reduce spending without compromising quality of care or enhance quality of care without increasing spending (section 1115A of the Act)

However, it has only a limited use in clinical practice due to its severe adverse effects, particularly nephrotoxicity

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Common symptoms may include: Persistent tiredness or fatigue Weakness Shortness of breath Pale skin Pins and needles Difficulty concentrating Memory problems Low mood If symptoms are severe, prolonged or worsening, it is important to seek professional medical advice

The gut is filled with different strains of good and bad bacteria