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began high-throughput screening in the early 20th century in search of new small-molecule anti-cancer therapies, and in 2003 published a series of compounds that can induce a different mode of cell death from necrosis and apoptosis [43] (Table 1)

Leaky gut syndrome as a catch-all diagnosis that explains unrelated symptoms is not established and is best framed as a clinical hypothesis, not a proven cause

However, it is important to note that a range of issues, including drug resistance, may emerge in the future

Wixner J., Sundstrom T., Karling P., Anan I., and Suhr O

[DOI] [PubMed] [Google Scholar] 231.West N.P., Horn P.L., Pyne D.B., Gebski V.J., Lahtinen S.J., Fricker P.A., Cripps A.W