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Excessive testosterone production in PCOS is mainly due to the increased release of luteinizing hormone by the pituitary gland and the effects of a hyperinsulinemic state on the ovaries

The mechanism is purely metabolic: increased energy expenditure , suppressed lipogenesis, and elevated NAD+ levels that activate sirtuins (SIRT1, SIRT3), the same longevity-associated enzymes targeted by caloric restriction

However, its important to note that the safety of peptides can vary depending on the specific peptide, dosage, individual health conditions, and how they are used

Topically: When using grapefruit oil on your skin, it should be diluted with equal parts of a carrier oil, like coconut or jojoba oil

Without standardized quality control, peptide content, purity, sterility, and stability cannot be assured