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These include regulation of mechanisms controlling reactive oxygen species (ROS), which cause macromolecular damage 16,17 , mitochondrial turnover or mitophagy 18 , and the mitochondrial unfolded protein response (UPR mt ), in which mitochondrial damage can be prevented by the removal of aggregated or unfolded proteins 19

Understanding the root cause is essential for effective treatment and long-term management

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TB-500 and Post-Exertional Malaise Post-exertional malaise (PEM) the hallmark feature of ME/CFS-like long COVID is characterised by a disproportionate worsening of symptoms after physical or cognitive exertion