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In aging, pathological mechanisms triggered by increased IOP will affect neuronal tissue which is less resistant to glaucomatous damage (Burgoyne, 2011)

Interestingly, in human HCC with poorer prognosis (HCCP), higher MAT1A:MAT2A switch, CpG methylation, and histone H4 acetylation were found in human HCC with a better prognosis (HCCB) [33]