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However, challenges remain for in vivo applications and clinical translation

This negative impact on the sphingolipid biosynthesis pathway could explain other adverse effects, such as reduced intestinal epithelial cell viability and proliferation, modification of cytokine production, and impairment of intestinal physical barrier function

Consistently, MAX2 has been reported to be induced under various abiotic stress conditions 183 , and overexpression of CsMAX2 in transgenic lines resulted in reduced MDA accumulation under salt, drought, and ABA stress, highlighting its protective role in stress mitigation 75

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Intestinal disorders in horses are usually associated with colic