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Nat Prod Rep 32, 256272 (2015)

However, evidence suggests that intraperitoneal melatonin is not neuroprotective and may exacerbate neurodegeneration (Dardiotis et al., 2013)

Studies have demonstrated that induction of HO-1 expression in macrophages yields amplified antioxidant efficacy and mitigates the inflammatory aspect of atherosclerotic lesions