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To meet the diagnostic criteria for cEDS, a person must meet: Major criterion 1 AND major criterion 2 OR Major criterion 1 AND three or more minor criteria Major Criteria Skin hyperextensibility and atrophic scarring Generalized joint hypermobility Minor Criteria Easy bruising Soft, doughy skin Skin fragility (or traumatic splitting) Molluscoid pseudotumors Subcutaneous spheroids Hernia (or history thereof) Epicanthal folds Complications of joint hypermobility (e.g., sprains, dislocations/subluxations, pain, flexible flatfoot) Family history of a first-degree relative who meets clinical criteria Hypermobility Spectrum Disorders (HSD) HSD in Adults Adults are diagnosed with HSD if they have symptomatic joint hypermobility that cannot be explained by other conditions

Hormones, inflammation, poor circulation, nutrient deficiencies, oxidative stress, and structural weakness all contribute

Ophthalmic Res 55 , 3744 (2015)

Thoe in Palo Alto, where her father was a doctoral student at Stanford University, but grew up in Indiana where the high-powered AM radio stations in Chicago were home to superstar DJs such as Larry Lujack and John Landecker