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Metformin is recommended as the first-line treatment for type 2 DM, as it can improve endothelial dysfunction by enhancing endothelium-dependent vasodilation and reducing sympathetic overactivity, ultimately restoring erectile responses in the CC of DM animal models through the NO/cGMP pathway [168]

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Our results showed that TAT-CcSOD1 pretreatment could efficiently inhibit H 2 O 2 -induced NO generation in HaCaT cells The protective effect of TAT-CcSOD1 on oxidative stress in cells was similar to that of EGCG, the major component of green tea polyphenols which were reported to have strong antioxidant properties 62