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Discovery of novel lipid profiles in PCOS: do insulin and androgen oppositely regulate bioactive lipid production

The median progression-free (PF) and overall survival (OS) rates were 12.5 months and nearly 30 months respectively, but these outcomes did not reach statistical significance, and the study was not sufficiently powered for efficacy endpoints

There is supportive evidence indicating that elevated FDX1 expression facilitates cell death in LIHC, and patients with HCC who have high FDX1 expression exhibit increased immune cell infiltration compared to those with low expression [68]

The solvent was evaporated under reduced pressure to give the crude product, and the crude product was purified by mass triggered reverse phase HPLC (ACN/water with 0.1% TFA modifier) to afford the title compound

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