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Initial treatment for sepsis and renal failure, including intravenous bicarbonate and dialysis, failed to correct the acidosis

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Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons

Neurotrophic Factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer

First, given the very low expression of target (pHLA) in latently infected cells due to blocks in proviral transcription and translation, we anticipate that a multiple-dose schedule incorporating higher doses will be needed to provide sufficient target occupancy to drive substantial killing of infected cells and thereby achieve the multi-log reductions that are deemed necessary for long-term viral control 61