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Another ferroptosis inhibitor, liproxstatin-1 (LIP-1), has demonstrated potential cardioprotective effects by reducing the expression of voltage-dependent anion channel 1, thereby preserving mitochondrial integrity and mitigating myocardial infarction severity (211)

Extracellular LDH Activity as a Measurement for Cytotoxicity The release of lactate dehydrogenase (LDH) into culture supernatant correlated with the amount of cell death and membrane damage, providing an accurate measure of cellular toxicity

Moreover, c-Myc upregulates OXPHOS in various cancer cell lines, with high levels of endogenous c-Myc observed under normoxic conditions

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Consequently, they cannot perform SIM measurements for transmission type mass spectrometry