They may take you back down to a lower dose , at least temporarily , to see if that works better for you
For example, the choroid plexus, a structure in the brain that produces cerebrospinal fluid, may serve as a gateway for monocyte infiltration into the CNS [170]
Recent studies looking at the telomeric proteome during replication observed high levels of histone protein H1 at telomeres during replication (Lin et al 2021), and cells that had H1 depleted through knockout experiments are sensitive to DNA damage and double strand breaks (Murga et al 2007)
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These studies are presented below