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After 30 days of oral administration to 5-month-old transgenic mice, these mycelia were able to attenuate cerebral A plaque burden, prevent recruitment and activation of plaque-associated microglia and astrocytes, promote the expression of IDE, increase the NGF-to-NGF precursor (proNGF) ratio, and enhance the proliferation of neuron progenitors and the number of newly born neurons in the dentate gyrus region [43]

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