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Wiley Online Libr 177:375387

In organoids derived from intestinal epithelial cells from global knockout mice for the Atp7b gene ( Atp7b -/- ) there is dysregulated lipid metabolism but the systemic effects of the intestinal Atp7b mutation and its significance in affecting the phenotype are unknown

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These, and similar studies cannot reliably distinguish between a true lack of effect of vitamin C and an apparent lack of effect, because the intervention groups were likely already replete in vitamin C and were not substantially different from the control groups with regard to the vitamin, even with supplementation (Rumbold et al., 2006, Padayatty & Levine, 2006, Sesso et al., 2008, Padayatty & Levine, 2009, Fortmann et al., 2013, Padayatty & Levine, 2014, Isanaka et al., 2012, Padayatty & Levine, 2013)

The numerous enzymatic sources of ROS include mitochondria and multiple isoforms of NOXs